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Tschuck J, Nair VP, Galhoz A, Ciceri G, Rothenaigner I, Tchieu J, Tai H-M, Stockwell BR et al (2023) Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

Some of these have stronger clinical support than others

doi: 10.1016/j.freeradbiomed.2013.09.009

This exceptional potency translates to pronounced improvements in synaptic connectivity in preclinical models

The problem is in the gut, so delivering the compound directly to the gut lining is the most logical and effective approach

For instance, specific steps of TH signaling in lipid metabolism that are influenced by n-3 PUFA include higher liver expression of the thyroid hormone nuclear receptor TR1 and mitochondrial -glycerophosphate dehydrogenase (109)