TB-500 has been studied for its ability to promote angiogenesis, support stem cell proliferation, inhibit apoptosis, and reduce inflammatory reactions and damage
The initial definition of TAM subsets based on M1 (pro-inflammatory and tumor suppressing) and M2 (anti-inflammatory and promoting tumor progression) (35, 38, 39) was recently overcome by a more heterogenous definition based on transcriptional programs representative of different phenotypes and functions, including activation and cytokine production (4043)
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Then, the sections were coated with an anti-CD31 antibody (Santa Cruz Biotechnology, Dallas, TX) at 4 C overnight, followed by incubation with an HRP-labeled secondary antibody (Gene Tech, Shanghai, China), and the sections were visualized with a DAB system (Gene Tech)
J Cosmet Dermatol 19:34083413
