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When melanin is overproduced or unevenly distributed, visible darkened areas can develop, presenting as hyperpigmentation or patchy tone

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Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes

In contrast, other studies have found that E2 inhibited receptor activator of nuclear factor-B ligand (RANKL)-induced upregulation of oxidative phosphorylation (197199)

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In addition to their transport functions, MCTs also participate in lactate-mediated signaling