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While GLP-1 agonists primarily work through appetite suppression (the input side of the energy equation), glucagon activation works on the output side, increasing how many calories the body burns at rest

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At first, shots might be given weekly or every two weeks

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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)

DOI: 10.1016/S0140-6736(23)01163-7