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As a potent Nrf2 activator, SF addresses both systemic and brain-specific oxidative stress and inflammation as well as improving mitochondrial bioenergetics and metabolic resilience

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PLoS Genet 14:e1007310

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Among these, the CRL4 E3 ligase comprised of the scaffold protein CUL4A/B, the catalytic subunit RBX1 and the adaptor protein DDB1

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