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It binds the ghrelin / growth-hormone secretagogue receptor (GHS-R1a) on the pituitary, mimicking the natural hormone ghrelin and triggering a short, pulsatile release of growth hormone [1] [2]

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The presence of an extra X chromosome (Klinefelter syndrome) or an extra Y chromosome, the presence of two X but no Y chromosome in a male, and microdeletions or translocations affecting the X or Y chromosome are examples of chromosomal problems that can disrupt sperm production and overall genital and gonad development, resulting in azoospermia (absence of sperm) and infertility

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This mode that neutrophils die with the extrusion of cytoplasmic contents to form NETs, is called NETosis