Plant, Cell & Environment 35 (2)
After structural optimization, this inhibitor exhibited high selectivity for SQOR over other mitochondrial enzymes, effectively avoiding off-target effects
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
Collectively, these findings indicate that non-selective or excessive chelation of brain iron may disrupt physiological metallostasis, emphasizing the need for precisely titrated, brain-targeted anti-ferroptotic interventions with balanced efficacytoxicity profiles. Beyond traditional chelators, several natural compounds have also shown potential in regulating iron transport proteins
Risk of anaphylaxis with repeated courses of rasburicase: a Research on Adverse Drug Events and Reports (RADAR) project
Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness