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Due to the status of pyritinol as a dietary supplement in some countries, it can be safely used as an adjunct to any standard treatment of CNS diseases, such as developmental dysphasia and other cognitive disorders, for which current therapeutic options are limited [90]

Furthermore these diseases are often comorbid with up to 25% of AD patients with FTD and FTD patients that do not have a comorbid diagnosis with AD have a significantly lower fraction of A than those who do (Tan et al., 2017)

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SESN1 Sestrin 1 (SESN1) belongs to the growth arrest and DNA damage-inducible gene (GADD) family [16, 17], with ubiquitous expression in human tissues including skeletal muscle, heart, liver, and brain [18]

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1, the first batch of MD simulations was carried out for 2 wild type nanobody systems (PV2-WT and PV3-WT) and 1 antigen system (PD-L1) at 300 K