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B12 injections effectively treat deficiency symptoms including chronic fatigue, mental fog, memory problems, numbness or tingling in extremities, pale skin, general weakness, and irritability in affected patients.

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In:VerhoeckxKCotterPLpez-ExpsitoIKleivelandCLeaTMackieAetal., editors

And for many women, it works well

Although a few studies have been conducted in humans, the results are mixed and ultimately the drug is not approved by the US Food and Drug Administration (FDA)

The stomach's acidic pH (1.5-3.5) and proteolytic enzymes present major challenges for peptide stability