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Enzyme Activation Lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers (essential for tissue strength, elasticity, and proper matrix organization), absolutely requires copper as a cofactor - GHK-Cu enhances lysyl oxidase activity by ensuring adequate copper availability, thereby promoting proper collagen and elastin maturation and tissue structural integrity

Blood 134 , 3253 (2019)

The major in vitro readout is increased dendritic spine density in rat hippocampal neuron cultures (approximately three-fold over vehicle in the McCoy 2013 work)

Citing our past work, describe how we demonstrated feasibility for the innovation described in the topic document