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CRC Crit Rev Biochem 23:283337 Meech R, Mackenzie PI (1997) Structure and function of uridine diphosphate glucuronosyltransferases

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Decreased glutathione levels and impaired antioxidant enzyme activities in drug-naive first-episode schizophrenics

Consistently, redox proteomics studies did not point to much redox PTMs except that AtAPR1, 2, and 3 could become persulfidated under S-sufficient media ( Four APK proteins exist in Arabidopsis, APK1, 2, and 4 locate in plastids whereas APK3 is in the cytosol (Mugford et al., 2009)

Given the epidemiology linking each of these independently to increased AD risk, targeting senescent cells in early disease stages (preclinical and/or prodromal) may hold promise to prevent chronic neurodegeneration and dementia

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