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The two coronavirus sites with exact P4-P1 matches to GCLC are those at either end of nsp5, i.e., M pro itself, which have the highest catalytic efficiency for cleavage of any of the viral M pro targets (100 and 41%)

Nuclear receptor activator 4 (NCOA4) can bind to ferritin and deliver it to lysosomes for degradation, thereby increasing the iron concentration in cells and ultimately promoting ferroptosis (Fig

These findings indicate that mitochondrial uncoupling via HU6 can effectively reduce hepatic steatosis and support weight loss in patients with MASLD

Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

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Changes in the levels of plasma biomarkers corroborate with the results of postmortem studies on ASD patients