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Lower oxidative stress may support more efficient NAD+ use* High oxidative stress can place increased demand on NAD+

Myogenic differentiation quantified through real-time PCR showing increased MyoD and myogenin expression

Ganz, T

Inflammation modulation Inflammation is a necessary part of the wound healing process, but excessive or prolonged inflammation can impede recovery

The resulting glutamate overstimulation of NMDA and metabotropic glutamate receptors (mGluRs) further complicates the situation, whereby mGluR activation via phospholipase C (PLC) and inositol trisphosphate (IP 3 ) signaling prompts Ca 2+ overload [138]

10.1136/annrheumdis-2019-215920 103 SchererH