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KPV is made from lysine-proline-valine, a naturally occurring tripeptide with anti-inflammatory and antimicrobial effects

The peptide acts as a signaling molecule, influencing gene expression i n approximately 31% of the hum an genome, promoting tissue regeneration, collagen synthesis , and antioxidant protection.

These metabolites were categorized into 34 categories (Table S4)

Methionine-derived SAM sustains defense gene induction by regulating histone methylation

Ibuprofen causes stomach irritation and bleeding, while acetaminophen poses a higher risk of liver damage if taken in excess.

Supplementary information Supplementary Table 1 (download XLSX Proteomics, cryo-EM data collection, genetic screens and RNA-Seq