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Serious hypoglycemia or major cardiac events remain rare

Optimal dosing is also an open question

Not recommended for individuals with known sensitivity to copper-based compounds

But it came with what researchers call "retinoid dermatitis": inflammation mediated by MCP-1 and IL-8 cytokine release, barrier disruption from transepidermal water loss, and photosensitivity from exposing fresh, immature cells to UV

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