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Yes, especially when combined with a calorie-restricted diet and strength exercise

10.1016/j.phymed.2024.155586 71 LuoQ.WuX.ZhaoP.NanY.ChangW.ZhuX.et al (2021)

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One participant was excluded owing to incomplete MRI data caused by discomfort in the scanner, and two participants were excluded owing to excessive head motion, leaving 25 participants suitable for the casecontrol analysis (Extended Data Table 1

While NAC boosts glutathione production indirectly, direct glutathione supplements offer immediate support