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Wang Y, Wang W, Li D, Li M, Wang P, Wen J, et al

Clinical studies have tested doses up to 1000 mg or even 2000 mg daily of NR and found them to be well-tolerated with no serious adverse effects

In summary, how to specifically inhibit the amino acid metabolism of tumor cells and immunosuppressive cells in the microenvironment, and enhance the amino acid metabolism of anti-tumor immune cells such as CD8 + T cells, is an urgent problem to be solved

Also, IGF-1 phosphorylates and activates the -1 subunit of the L-type Ca 2+ channel through the PI3K pathway [73]