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doi: 10.1016/j.jid.2019.01.023 114 SugaHSugayaMMiyagakiTKawaguchiMMorimuraSKaiHet al

Under transmission electron microscopy, EVs secreted by Sertoli cells can be observed around all levels of germ cells, which helps regulate the growth and development of germ cells

As previously described the viral infection induced an increase in ROS production directly in CNS cells or indirectly by the infiltrated activated immune system cells, which use ROS release as mechanism to control the infection (Figure 3)

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Consequently, any impairment of liver function, particularly in individuals with chronic liver disease, can lead to substantial alterations in iron regulation [3, 29]