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During the development of insulin resistance, the proportion of FLTP-low cells increases, accompanied by reduced insulin secretion (Rubio-Navarro et al., 2023)

doi: 10.3389/fimmu.2024.1386856 194 ZhengXOuyangXChengCRongLChenLMoYet al

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doi: 10.1038/s41419021-034825 262 YangWHDingCCSunTRupprechtGLinCCHsuDet al

However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives