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In Experiment 2, to determine the effects of NAC on behavioral scores and CNS metabolites after acute withdrawal, all methadone-exposed pups received naloxone HCl (1 mg/kg, i.p.) and either NAC (50 mg/kg, n = 2, or 100 mg/kg, n = 7) or an equal volume of saline i.p

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Distinct effects of inflammation on cytochrome P450 regulation and drug metabolism: Lessons from experimental models and a potential role for pharmacogenetics