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1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]

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So for every glucose 6 Phosphate that gets into the HMP Shunt, 2 NADPH is formed

doi:10.1093/cid/cir257

Not only was this valuable to my understanding of the experimental process, my frustration gave me a new appreciation for the timeframe of research