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This is to avoid genomic instability and propagation of the induced damage to progeny cells [55]

The Native Americans, from whom the first Western explorers learnt about tobacco, used the leaf for a variety of purposes, including religious worship, but Europeans soon became aware that the Americans also used tobacco for medicinal purposes

The MSA-funded Truth campaign (formerly the American Legacy Foundation, established with $2.5 billion in settlement funds) also spends most of its budget on research, with a modest amount going for paid mass media, but with restrictions on the mention of tobacco company names and cigarette brand names

Manzano C, et al

The 'Journal of Preventive Medicine' interviewed 840 educated young adults and found that 23% had used e-cigarettes

This observation may be related to critical developmental periods of the prefrontal cortex during this age range, as well as increased time spent within the household environment 32