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Avoid Requiring Human Studies It is possible to characterize the risks associated with vaping by analyzing the devices emissions under realistic operating conditions, and there is no need to add to the burdens on applicants by requiring biomarker or pharmacokinetic studies

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Reducing nicotine levels in cigarettes could complement these strategies and bring us one step closer to a society free of tobacco-related disease and death. Cigarette smoking remains the leading cause of preventable disease and death in the United States, responsible for an estimated 480,000 deaths each year

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