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These include: Endogenous reactive metabolites such as products arising from oxidative metabolism of lipids, nucleic acids and catecholamines Xenobiotics which are not normally found in the body and can include naturally occurring compounds or they can be man made in origin such as drugs or environmental pollutants Heavy metals such as mercury, lead, cadmium and arsenic The chemical reactivity of many of these compounds cause interference with the normal biological processes and hence they are toxic
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Likewise it is an example of hemolytic anemia due to an interaction between extra cellular and intracellular causes, since hemolysis in most cases is triggered by exogen agents 25
It simultaneously upregulates the synthesis of new matrix proteins like collagen and the breakdown of old, scarred proteins via matrix metalloproteinases (MMPs)
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