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Compounding allows prescribers to adjust the hydroquinone concentration beyond the 4% ceiling of most commercial products and to customize the vehicle for patient tolerance

Yaku, K., Okabe, K., Hikosaka, K

Twice Daily Protocol: Splitting the daily dose into morning and evening administrations (0.05 to 0.075 mg each) maintains more consistent tissue levels

Circulation , 144 22, 1795-1817

GSH is critically important for scavenging reactive oxygen species (ROS) generated by mitochondria 30 , and is also a substrate for antioxidant enzymes that detoxify hydrogen peroxide and lipid peroxides 59

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