Local Coverage Determination Reference The Centers for Medicare & Medicaid Services (CMS) local coverage determination remains the authoritative source for Part B criteria regarding B12 injections
Fine for larger doses, but problematic if you need 100 mcg, because 100 mcg would be just 0.02 mL, or 2 units on the syringe
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It is important not to self-treat with high-dose B12 supplements before seeing your GP if you suspect deficiency, as this can interfere with diagnostic blood tests and potentially mask underlying conditions such as pernicious anaemia
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Patients should also be aware that certain medicationssuch as proton pump inhibitors (PPIs) and metformincan interfere with B12 absorption, though this is less relevant once on injection therapy