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When the body is in a state of hypoxia, infection, intense exercise, etc, and the cells demand for ATP increases, pyruvate and NADH tends to be directly catalyzed by lactate dehydrogenase (LDH) to produce lactate, rather than entering the mitochondria to participate in the tricarboxylic acid cycle (TCA)

Additionally, BPC-157 exhibits neuroprotective effects and may influence dopaminergic and serotonergic systems

Handog EB, Datuin MS, Singzon IA

Targeting p300/CBP Although lactylation has only recently emerged as a novel epigenetic modification, mounting preclinical evidence has illuminated its critical role in regulating tumor metabolism, immune evasion, and therapy resistance

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